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ADVERTISEMENTFinally, our study had a modest sample size, and subgroup analyses by melanoma sites and other factors, particularly nevi,37 were underpowered. Prior studies have shown that melanomas on the trunk more frequently harbored BRAF mutations than those on the head and neck.38BRAF and NRAS mutations also tend to occur exclusively.4 Additional studies are required to investigate sildenafil use and melanoma risk by BRAF/NRAS mutations and body sites.

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