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Physicians should discuss with patients the contraindication of Viagra with regular and/or intermittent use of nitric oxide donors, such as organic nitrates or organic nitrites in any form [see Contraindications (4.1)].Physicians should advise patients to stop use of all phosphodiesterase type 5 (PDE5) inhibitors, including Viagra, and seek medical attention in the event of a sudden loss of vision in one or both eyes. Such an event may be a sign of non-arteritic anterior ischemic optic neuropathy (NAION), a rare condition and a cause of decreased vision including permanent loss of vision, that has been reported rarely post-marketing in temporal association with the use of all PDE5 inhibitors. Based on published literature, the annual incidence of NAION is 2.5–11.8 cases per 100,000 in males aged ≥ 50. An observational study evaluated whether recent use of PDE5 inhibitors, as a class, was associated with acute onset of NAION. The results suggest an approximate 2 fold increase in the risk of NAION within 5 half-lives of PDE5 inhibitor use. From this information, it is not possible to determine whether these events are related directly to the use of PDE5 inhibitors or to other factors [see Adverse Reactions (6.2)]. levitra side effects alcohol Tadalafil is a selective, reversible inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5). When sexual stimulation causes the local release of nitric oxide, inhibition of PDE5 by tadalafil produces increased levels of cGMP in the corpus cavernosum. This results in smooth muscle relaxation and inflow of blood into the penile tissues, thereby producing an erection. Tadalafil has no effect in the treatment of erectile dysfunction in the absence of sexual stimulation.


According to statistics, 1 in 10 men experience impotence at least at some point in their lives. However common this may be, dealing with it doesn’t make it any much easier. The effects of impotence on a male would mostly be psychological - normally of fear and anxiety about it. Good thing, oral drugs have been developed over the past few years to help a patient restore enjoyment and intimacy with his partner - and one of which is Viagra.Persons surnamed "Cialis" objected to Eli Lilly and Company's so naming the drug, but the company has maintained that the drug's trade name is unrelated to the surname.[14] cheap cialis canadian Manufacturer Coupons and Rebates hivesA locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines.If you take too much (Overdose)

Applies to sildenafil: intravenous solution, oral suspension, oral tablet cialis daily use side effects Journal Reference:

Change from baseline 1.2 6.1c 7.0c <.001 0.9 9.7c <.001

are allergic to sildenafil, as contained in Viagra and REVATIO, or any of the ingredients in Viagra. See the end of this leaflet for a complete list of ingredients in Viagra.The US Food and Drug Administration has approved a libido-enhancing drug for women dubbed the "female Viagra". buy viagra now a physical deformity of the penis (such as Peyronie's disease); orLevitra 10 mg Label

USE IN SPECIFIC POPULATIONSConcomitant use of nitrates in any form is contraindicated [see Contraindications (4.1)].

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