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Approved by the FDA in 1998, sildenafil (Viagra) revolutionized the way we think about — and treat — erectile dysfunction (ED), largely because it is effective and easy to use. In 2003, the FDA approved two closely related drugs, vardenafil (Levitra) and tadalafil (Cialis). Five years later, in January 2008, low-dose Cialis for daily use came onto the market, creating an option that — theoretically, at least — makes having sex a possibility without advance planning.All three drugs work in a similar fashion, by affecting the normal physiology of the penis. In particular, they block PDE5, an enzyme that breaks down the erection-producing chemical cyclic guanosine monophosphate. This enables the penis to fill with blood and to stay erect long enough for intercourse. Of course, it’s important to realize that none of these drugs is an aphrodisiac. You must feel sexually aroused in order for them to work.The main differences between the three drugs have to do with timing: how quickly they begin to work, and how long their effects last (see Table 4). The biggest divide lies between Cialis for daily use, which keeps a steady supply of the drug in the bloodstream, and the as-needed dosing offered by the original form of Cialis, as well as by Levitra and Viagra. Among the nondaily pills, Levitra may start working slightly faster than Viagra (within a half-hour instead of an hour) although the FDA says that like Viagra, it should be taken about an hour before sexual activity. Some studies suggest that Levitra may help some men who don’t respond to Viagra. And while some doctors are skeptical about this claim, there’s no harm in trying Levitra or Cialis if Viagra doesn’t work for you.A CYP3A4 inducer, rifampicin, reduced tadalafil AUC by 88%, relative to the AUC values for tadalafil alone (10 mg). This reduced exposure can be anticipated to decrease the efficacy of tadalafil; the magnitude of decreased efficacy is unknown. Other inducers of CYP3A4, such as phenobarbital, phenytoin, and carbamazepine, may also decrease plasma concentrations of tadalafil. how does cialis work Mechanism of Action

Stop using vardenafil and get emergency medical help if you have sudden vision loss.Placebo Cialis

if you have heart or blood vessel problems that make sexual intercourse inadvisable.Consider a starting dose of 25 mg in patients treated with strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, or saquinavir) or erythromycin. Clinical data have shown that co-administration with saquinavir or erythromycin increased plasma levels of sildenafil by about 3 fold [see Drug Interactions (7.4) and Clinical Pharmacology (12.3)]. viagra cheap online Trials in a General Erectile Dysfunction Population? cisaprideBut do the benefits outweigh the risks? That's something only the women taking these drugs, with the advice of their doctors, can decide. With trials seeing women reporting around one extra sexually gratifying experience a month, this is not perhaps the wonder drug so many women were hoping for.

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Cialis was approved by the FDA in 2009 for the treatment of pulmonary arterial hypertension. viagra reviews There were no treatment-related testicular findings in rats or mice treated with doses up to 400 mg/kg/day for 2 years. swelling in your hands, ankles, or feet;Tadalafil works by preventing the action of a chemical in your body, called phosphodiesterase type-5. This helps to relax (widen) blood vessels and improves the flow of blood to the penis following sexual stimulation. This helps to maintain an erection.

joe; No this is not a cure you would have to use this each time for sex. This is caused if I am seeing right looks like you are taking an SSRI medication and this is a very common side effect that they do use Viagra to help while your on the medication This well continue as long as you are having the side effect from whatever medication you are taking. Really nothing to worry about you well return to normal when the medication is stopped or you try something different. Really nothing to worry about.Have a good day.

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